2022 Spring
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Browsing 2022 Spring by Author "Eubank, Jarrod F."
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Item Analysis of Metal-Organic Framework Stability, Antimicrobial Properties, and Dental Applications(Florida Southern College, 2022-05) Marusko, Benjamin; Eubank, Jarrod F.; Langford, Melanie L.The development of metal-organic frameworks (MOFs), an analysis of their properties, and exploration of their potential biomedical applications, specifically dental, are areas of modern biochemical interest focus on through this study. Previous research has shown these frameworks (and/or their components) have the potential for antimicrobial properties, and we hypothesized that they may be used on dental implants to inhibit the growth of oral bacteria responsible for peri-implantitis. This project has consisted of the development and structural analysis of several different novel frameworks with a high potential for microbial inhibition. Through the incorporation of antimicrobial metal ions, bridging ligands, and possibly terminal ligands there is the potential for a synergistic antimicrobial effect greater than any of the individual components. Structural stability has been monitored under varying environmental conditions, such as humidity; changes have been recorded and analyzed for potential functional applications in biological conditions. A common characteristic of MOFs is the modularity of components, which could allow for the addition of drug compounds or ligands with higher antimicrobial effects for a stronger inhibition of bacterial growth. Key MOFs were selected for antimicrobial analysis through Kirby-Bauer inhibition tests on the common oral bacteria, Streptococcus mutans (S. mutans). The frameworks presenting significant bacterial inhibition were then tested for the potential of growth directly onto the titanium implants used in a majority of oral surgeries. Our research project has resulted in novel MOFs with antimicrobial properties that can be further functionalized and grown directly onto titanium implants for the prevention of infection immediately post oral surgery.Item An Inquiry into the Synthesis of Zinc/Chelidonate-based MOFs and Their Potential Uses in the Prevention of Hernia Mesh Infections(Florida Southern College, 2022-05) Vassalotti, Ryan; Eubank, Jarrod F.A hernia is one of the most common medical issues that occurs in the entire world, affecting millions of people yearly. As part of the surgery to repair a hernia, the physician will often insert a mesh material to prevent recurrence of the hernia. Despite their high efficacy in preventing recurrence of the hernia, these hernia meshes are unfortunately prone to infection. Hernia mesh infections affect thousands of people every year and cost the individuals large amounts of unnecessary time and money. The field of metal-organic frameworks (MOFs) has opened up a promising path towards solving this issue. The successful synthesis of antimicrobial MOFs and biocompatible MOFs demonstrates that there is merit in pursuing biomedical applications. With the help of antimicrobial materials like MOFs it may be possible to prevent these postoperative infections. Synthesis of a Zn-based analogue to a previously characterized antimicrobial Cu-basedMOF, me137, was successful. The results of this study indicate that control of both morphology and structure in Zn-based MOFs is possible. Additionally, the Zn-based MOFs appear to be more chemically stable than similar Cu-based MOFs. Antimicrobial assays have demonstrated that the Zn-based MOFs are capable of inhibiting the growth of E. coli and S. aureus. Early adhesion tests have shown that growth of Compound 1 (RV22) onto unmodified polypropylene is not an interaction that readily occurs. Thus, methods for modifying polypropylene to take on a form more conducive to MOF adhesion was investigated. A method for oxidizing polypropylene with the use of KMnO4, NaOH, and heat was found to be successful, but adhesion of Compound 1 onto the oxidized polypropylene has not yet been achieved.