Florida Southern College Digital Repository

Chaperone proteins as ameliorators of α-synuclein-induced synaptic pathologies: Insights into Parkinson's disease

Show simple item record

dc.contributor.author Banks, Susan M. L.
dc.contributor.author Medeiros, Audrey T.
dc.contributor.author Sousa, Rui
dc.contributor.author Lafer, Eileen M.
dc.contributor.author Morgan, Jennifer R.
dc.date.accessioned 2022-06-20T16:23:03Z
dc.date.available 2022-06-20T16:23:03Z
dc.date.issued 2021-06
dc.identifier.citation Banks, S. M. L., Medeiros, A. T., Sousa, R., Lafer, E. M., & Morgan, J. R. (2021). Chaperone proteins as ameliorators of α-synuclein-induced synaptic pathologies: Insights into Parkinson’s disease. Neural Regeneration Research, 16(6), 1198-1199. https://doi.org/10.4103/1673-5374.300431 en_US
dc.identifier.other https://doi.org/10.4103/1673-5374.300431
dc.identifier.uri http://hdl.handle.net/11416/634
dc.description.abstract Neurodegenerative disorders, such as Parkinson’s disease (PD) and other synucleinopathies, impact the lives of millions of patients and their caregivers. Synucleinopathies include PD, dementia with Lewy Bodies (DLB), multiple system atrophy, and several Alzheimer’s Disease variants. They are clinically characterized by intracellular inclusions called Lewy Bodies, which are rich in atypical aggregates of the protein α-synuclein. While dopaminergic neurons in the substantia nigra are particularly susceptible to α-synuclein-induced aggregation and neurodegeneration, glutamatergic neurons in other brain regions (e.g. cortex) are also frequently affected in PD and other synucleinopathies (Schulz-Schaeffer 2010). Several point mutations in the α-synuclein gene (SNCA), as well as duplication/triplication of SNCA, are linked to familial Parkinson’s disease.
dc.language.iso en_US en_US
dc.publisher Wolters Kluwer Medknow Publications en_US
dc.subject Parkinson's disease en_US
dc.subject Alpha-synuclein en_US
dc.subject Molecular chaperones en_US
dc.title Chaperone proteins as ameliorators of α-synuclein-induced synaptic pathologies: Insights into Parkinson's disease en_US
dc.type Article en_US


Files in this item

This item appears in the following Collection(s)

Show simple item record

Search


Browse

My Account