Auxilin is essential for Delta signaling
Date
2008-03
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Publisher
Company Of Biologists Limited
Abstract
Endocytosis regulates Notch signaling in both signaling and receiving cells. A puzzling observation is that endocytosis of transmembrane ligand by the signaling cells is required for Notch activation in adjacent receiving cells. A key to understanding why signaling depends on ligand endocytosis lies in identifying and understanding the functions of crucial endocytic proteins. One such protein is Epsin, an endocytic factor first identified in vertebrate cells. Here, we show in Drosophila that Auxilin, an endocytic factor that regulates Clathrin dynamics, is also essential for [...]
Description
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Keywords
Auxilins, Drosophila Proteins, Membrane Proteins, Adaptor Proteins, Intracellular Signaling Peptides and Proteins
Citation
Eun, S. H., Banks, S. L., & Fischer, J. A. (2008). Auxilin is essential for Delta signaling. Development (Cambridge, England), 135(6), 1089-1095. doi:10.1242/dev.009530