Generation of Controlled Release Gelatin-NSAID Conjugates for Post-Surgical Applications

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Florida Southern College
Nonsteroidal anti-inflammatory drugs (NSAIDs) are often prescribed after surgery to reduce inflammation and aid in pain management. NSAIDs, such as Advil, Motrin, and Aleve, are typically taken orally as over-the-counter medication. While these drugs are typically safe in small doses, sustained intake of high doses can have adverse side effects. The goal of this project was to design a product that would allow for direct application of NSAIDs to the surgical site, avoiding systemic circulation. By conjugating the NSAID to a gelatin hemostatic agent, the product can be applied to the open site and provide a subcutaneous delayed release. Type B gelatin was conjugated to the NSAID diclofenac using 1-ethyl-3-(-3-dimethylaminopropyl) carbodiimide (EDC) as the cross-linking agent. UV-Vis spectrometry confirmed concentrations eluted across different time frames to confirm the presence of a controlled release system. Use of this new technology in post-operative scenarios may help to lower NSAID intake, efficiently aid in patient pain management, and improve surgical protocols.
Honors Thesis Spring 2021
Nonsteroidal anti-inflammatory agents, Drugs -- Side effects, Surgery, Operative