Generation of Controlled Release Gelatin-NSAID Conjugates for Post-Surgical Applications
| dc.contributor.advisor | Shelby, Shameka J. | |
| dc.contributor.author | Rozen, Emily | |
| dc.date.accessioned | 2021-05-07T01:04:55Z | |
| dc.date.available | 2021-05-07T01:04:55Z | |
| dc.date.issued | 2021-05 | |
| dc.description | Honors Thesis Spring 2021 | en_US |
| dc.description.abstract | Nonsteroidal anti-inflammatory drugs (NSAIDs) are often prescribed after surgery to reduce inflammation and aid in pain management. NSAIDs, such as Advil, Motrin, and Aleve, are typically taken orally as over-the-counter medication. While these drugs are typically safe in small doses, sustained intake of high doses can have adverse side effects. The goal of this project was to design a product that would allow for direct application of NSAIDs to the surgical site, avoiding systemic circulation. By conjugating the NSAID to a gelatin hemostatic agent, the product can be applied to the open site and provide a subcutaneous delayed release. Type B gelatin was conjugated to the NSAID diclofenac using 1-ethyl-3-(-3-dimethylaminopropyl) carbodiimide (EDC) as the cross-linking agent. UV-Vis spectrometry confirmed concentrations eluted across different time frames to confirm the presence of a controlled release system. Use of this new technology in post-operative scenarios may help to lower NSAID intake, efficiently aid in patient pain management, and improve surgical protocols. | en_US |
| dc.identifier.uri | http://hdl.handle.net/11416/559 | |
| dc.publisher | Florida Southern College | en_US |
| dc.subject | Nonsteroidal anti-inflammatory agents | en_US |
| dc.subject | Drugs -- Side effects | en_US |
| dc.subject | Surgery, Operative | en_US |
| dc.title | Generation of Controlled Release Gelatin-NSAID Conjugates for Post-Surgical Applications | en_US |
| dc.type | Thesis | en_US |