Chaperone proteins as ameliorators of α-synuclein-induced synaptic pathologies: Insights into Parkinson's disease

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dc.contributor.authorBanks, Susan M. L.
dc.contributor.authorMedeiros, Audrey T.
dc.contributor.authorSousa, Rui
dc.contributor.authorLafer, Eileen M.
dc.contributor.authorMorgan, Jennifer R.
dc.date.accessioned2022-06-20T16:23:03Z
dc.date.available2022-06-20T16:23:03Z
dc.date.issued2021-06
dc.description.abstractNeurodegenerative disorders, such as Parkinson’s disease (PD) and other synucleinopathies, impact the lives of millions of patients and their caregivers. Synucleinopathies include PD, dementia with Lewy Bodies (DLB), multiple system atrophy, and several Alzheimer’s Disease variants. They are clinically characterized by intracellular inclusions called Lewy Bodies, which are rich in atypical aggregates of the protein α-synuclein. While dopaminergic neurons in the substantia nigra are particularly susceptible to α-synuclein-induced aggregation and neurodegeneration, glutamatergic neurons in other brain regions (e.g. cortex) are also frequently affected in PD and other synucleinopathies (Schulz-Schaeffer 2010). Several point mutations in the α-synuclein gene (SNCA), as well as duplication/triplication of SNCA, are linked to familial Parkinson’s disease.
dc.identifier.citationBanks, S. M. L., Medeiros, A. T., Sousa, R., Lafer, E. M., & Morgan, J. R. (2021). Chaperone proteins as ameliorators of α-synuclein-induced synaptic pathologies: Insights into Parkinson’s disease. Neural Regeneration Research, 16(6), 1198-1199. https://doi.org/10.4103/1673-5374.300431en_US
dc.identifier.urihttps://doi.org/10.4103/1673-5374.300431
dc.language.isoen_USen_US
dc.publisherWolters Kluwer Medknow Publicationsen_US
dc.subjectParkinson's diseaseen_US
dc.subjectAlpha-synucleinen_US
dc.subjectMolecular chaperonesen_US
dc.titleChaperone proteins as ameliorators of α-synuclein-induced synaptic pathologies: Insights into Parkinson's diseaseen_US
dc.typeArticleen_US

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