Reducing synuclein accumulation improves neuronal survival after spinal cord injury

Spinal cord injury causes neuronal death, limiting subsequent regeneration and recovery. Thus, there is a need to develop strategies for improving neuronal survival after injury. Relative to our understanding of axon regeneration, comparatively little is known about the mechanisms that promote the survival of damaged neurons. To address this, we took advantage of lamprey giant reticulospinal neurons whose large size permits detailed examination of post-injury molecular responses at the level of individual, identified cells.[...]

Keywords

CLR01, Lamprey, Molecular tweezer, Neurodegeneration, Parkinson's disease, Synaptotagmin

Citation

Fogerson, S. M., van Brummen, A. J., Busch, D. J., Allen, S. R., Roychaudhuri, R., Banks, S. M., & ... Morgan, J. R. (2016). Reducing synuclein accumulation improves neuronal survival after spinal cord injury. Experimental Neurology, 278105-115. doi:10.1016/j.expneurol.2016.02.004

URI

http://hdl.handle.net/11416/376
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Biology

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