Reducing synuclein accumulation improves neuronal survival after spinal cord injury

Date
2016-04
Authors
Fogerson, Stephanie M.
van Brummen, Alexandra J.
Busch, David J.
Allen, Scott R.
Roychaudhuri, Robin
Banks, Susan M. L.
Klärner, Frank-Gerrit
Schrader, Thomas
Bitan, Gal
Morgan, Jennifer R.
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier Inc.
Abstract
Spinal cord injury causes neuronal death, limiting subsequent regeneration and recovery. Thus, there is a need to develop strategies for improving neuronal survival after injury. Relative to our understanding of axon regeneration, comparatively little is known about the mechanisms that promote the survival of damaged neurons. To address this, we took advantage of lamprey giant reticulospinal neurons whose large size permits detailed examination of post-injury molecular responses at the level of individual, identified cells.[...]
Description
Keywords
CLR01, Lamprey, Molecular tweezer, Neurodegeneration, Parkinson's disease, Synaptotagmin
Citation
Fogerson, S. M., van Brummen, A. J., Busch, D. J., Allen, S. R., Roychaudhuri, R., Banks, S. M., & ... Morgan, J. R. (2016). Reducing synuclein accumulation improves neuronal survival after spinal cord injury. Experimental Neurology, 278105-115. doi:10.1016/j.expneurol.2016.02.004
DOI
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