The functions of auxilin and Rab11 in Drosophila suggest that the fundamental role of ligand endocytosis in notch signaling cells is not recycling
Date
2011-03-23
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Publisher
Public Library of Science
Abstract
Notch signaling requires ligand internalization by the signal sending cells. Two endocytic proteins, epsin and auxilin, are essential for ligand internalization and signaling. Epsin promotes clathrin-coated vesicle formation, and auxilin uncoats clathrin from newly internalized vesicles. Two hypotheses have been advanced to explain the requirement for ligand endocytosis. [...]
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Keywords
Endocytosis, Signal Transduction, Drosophila Proteins, Receptors, Notch, rab GTP-Binding Proteins, Vesicular Transport Proteins
Citation
Banks, S. L., Cho, B., Eun, S. H., Lee, J., Windler, S. L., Xie, X., & ... Fischer, J. A. (2011). The functions of auxilin and Rab11 in Drosophila suggest that the fundamental role of ligand endocytosis in notch signaling cells is not recycling. Plos One, 6(3), e18259. doi:10.1371/journal.pone.0018259