Banks, Susan M. L.Cho, BomsooEun, EunLee, Ji-HoonWindler, Sarah LXie, XuanhuaBilder, DavidFischer, Janice A.2018-03-282018-03-282011-03-23Banks, S. L., Cho, B., Eun, S. H., Lee, J., Windler, S. L., Xie, X., & ... Fischer, J. A. (2011). The functions of auxilin and Rab11 in Drosophila suggest that the fundamental role of ligand endocytosis in notch signaling cells is not recycling. Plos One, 6(3), e18259. doi:10.1371/journal.pone.00182591932-6203 (Electronic)http://hdl.handle.net/11416/378https://search.ebscohost.com/login.aspx?direct=true&AuthType=shib&db=mdc&AN=21448287&scope=site&custid=s5615486Notch signaling requires ligand internalization by the signal sending cells. Two endocytic proteins, epsin and auxilin, are essential for ligand internalization and signaling. Epsin promotes clathrin-coated vesicle formation, and auxilin uncoats clathrin from newly internalized vesicles. Two hypotheses have been advanced to explain the requirement for ligand endocytosis. [...]en-USEndocytosisSignal TransductionDrosophila ProteinsReceptors, Notchrab GTP-Binding ProteinsVesicular Transport ProteinsArticle