Auxilin is essential for Delta signaling

Date

2008-03

Journal Title

Journal ISSN

Volume Title

Publisher

Company Of Biologists Limited

Abstract

Endocytosis regulates Notch signaling in both signaling and receiving cells. A puzzling observation is that endocytosis of transmembrane ligand by the signaling cells is required for Notch activation in adjacent receiving cells. A key to understanding why signaling depends on ligand endocytosis lies in identifying and understanding the functions of crucial endocytic proteins. One such protein is Epsin, an endocytic factor first identified in vertebrate cells. Here, we show in Drosophila that Auxilin, an endocytic factor that regulates Clathrin dynamics, is also essential for [...]

Description

Keywords

Auxilins, Drosophila Proteins, Membrane Proteins, Adaptor Proteins, Intracellular Signaling Peptides and Proteins

Citation

Eun, S. H., Banks, S. L., & Fischer, J. A. (2008). Auxilin is essential for Delta signaling. Development (Cambridge, England), 135(6), 1089-1095. doi:10.1242/dev.009530

DOI

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