Analysis of the Antibiotic Susceptibility and Culture Conditions of Helicobacter Cetorum, a Seaborne Gastric Pathogen

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Florida Southern College
The Helicobacter genus is a diverse group of bacteria with many species that typically cause gastrointestinal disease in a variety of mammalian hosts. Helicobacter pylori is a well-studied pathogen in humans, is highly prevalent in the population, and causes gastritis, gastric ulcers, and carcinomas. [...] To date, very few publications have been released with studies of H. cetorum in the lab; most studies have focused exclusively on diagnosing infection and determining tissue pathology. In this study, we aimed to expand the existing knowledge on H. cetorum. In addition to analyzing certain growth condition preferences, we performed a series of tests to determine its susceptibility to the three aforementioned antibiotics commonly used to treat H. pylori. The bacteria was found to be sensitive to clarithromycin and levofloxacin, but resistant to metronidazole. These results may have clinical significance, as in vitro antibiotic susceptibility is directly correlated with in vivo antibiotic susceptibility, and the results can be used by marine veterinarians to better treat these intelligent, beautiful animals.
Honors Thesis Fall 2020
Helicobacter pylori, Gastrointestinal system -- Diseases, Marine mammals, Helicobacter infections